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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 2
2001 3
2003 3
2004 2
2005 1
2006 2
2007 2
2008 2
2009 1
2010 1
2015 1
2016 1
2018 4
2020 1
2021 2
2022 1
2024 0

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30 results

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Page 1
α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling.
Yuan Y, Zhu C, Wang Y, Sun J, Feng J, Ma Z, Li P, Peng W, Yin C, Xu G, Xu P, Jiang Y, Jiang Q, Shu G. Yuan Y, et al. Sci Adv. 2022 May 6;8(18):eabn2879. doi: 10.1126/sciadv.abn2879. Epub 2022 May 4. Sci Adv. 2022. PMID: 35507647 Free PMC article.
Previously, we found that alpha-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 (OXGR1). ...Mechanistically, we supported that extracellular AKG binds with a purinergic receptor, P2RX4, to initiate the solute carr …
Previously, we found that alpha-ketoglutaric acid (AKG) stimulates muscle hypertrophy and fat loss through 2-oxoglutarate receptor 1 …
P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.
Zech A, Wiesler B, Ayata CK, Schlaich T, Dürk T, Hoßfeld M, Ehrat N, Cicko S, Idzko M. Zech A, et al. Oncotarget. 2016 Dec 6;7(49):80288-80297. doi: 10.18632/oncotarget.13375. Oncotarget. 2016. PMID: 27863396 Free PMC article.
P2RX4 has been shown to interact with P2RX7 and promote NLRP3 inflammasome activation. ...Both, P2RX4 antagonist 5-BDBD treatment and P2rx4 deficiency resulted in an alleviated broncho alveolar lavage fluid eosinophilia, peribronchial inflammation, Th2 cytoki …
P2RX4 has been shown to interact with P2RX7 and promote NLRP3 inflammasome activation. ...Both, P2RX4 antagonist 5-BDBD treatm …
P2X7 as a scavenger receptor for innate phagocytosis in the brain.
Gu BJ, Wiley JS. Gu BJ, et al. Br J Pharmacol. 2018 Nov;175(22):4195-4208. doi: 10.1111/bph.14470. Epub 2018 Oct 5. Br J Pharmacol. 2018. PMID: 30098011 Free PMC article. Review.
P2X7 on the cell surface is present as a membrane complex, and an attachment to non-muscle myosin of the cytoskeleton is required for particle engulfment. Selective antagonists of P2X7 pro-inflammatory function have little effect on phagocytosis, but inheritance of a varia …
P2X7 on the cell surface is present as a membrane complex, and an attachment to non-muscle myosin of the cytoskeleton is required for …
TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex.
Notay K, Klingel SL, Lee JB, Doherty CJ, Seed JD, Swiatczak M, Mutch DM, Millar PJ. Notay K, et al. J Physiol. 2018 Nov;596(21):5135-5148. doi: 10.1113/JP276526. Epub 2018 Sep 19. J Physiol. 2018. PMID: 30206938 Free PMC article.
Common genetic variants of genes related to the vascular transduction of sympathetic outflow have been investigated, but variants influencing skeletal muscle afferent feedback during exercise have not been explored. Single nucleotide polymorphisms in TRPV1 rs222747 and BDK …
Common genetic variants of genes related to the vascular transduction of sympathetic outflow have been investigated, but variants influencin …
[Recent Findings on the Mechanism of Cough Hypersensitivity as a Cause of Chronic Cough].
Kamei J. Kamei J. Yakugaku Zasshi. 2021;141(12):1333-1342. doi: 10.1248/yakushi.21-00155. Yakugaku Zasshi. 2021. PMID: 34853206 Free article. Review. Japanese.
Two causes of dry cough are increased sensitivity of cough receptors (cough hypersensitivity) and increased contraction of bronchial smooth muscle. Among these, the mechanisms of cough hypersensitivity are diverse, and understanding these mechanisms is important for the di …
Two causes of dry cough are increased sensitivity of cough receptors (cough hypersensitivity) and increased contraction of bronchial smooth …
ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.
Walenta L, Fleck D, Fröhlich T, von Eysmondt H, Arnold GJ, Spehr J, Schwarzer JU, Köhn FM, Spehr M, Mayerhofer A. Walenta L, et al. Sci Rep. 2018 Jan 23;8(1):1431. doi: 10.1038/s41598-018-19624-3. Sci Rep. 2018. PMID: 29362497 Free PMC article.
We now show that human peritubular cells express purinergic receptors P2RX4 and P2RX7, which are functionally linked to TLRs, with P2RX4 being the prevalent ATP-gated ion channel. Subsequent ATP treatment of cultured peritubular cells resulted in up-regulated (pro-) …
We now show that human peritubular cells express purinergic receptors P2RX4 and P2RX7, which are functionally linked to TLRs, with …
Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring with Ventricular Pressure Overload.
Leu S, Wu KLH, Lee WC, Tain YL, Chan JYH. Leu S, et al. Nutrients. 2021 Sep 18;13(9):3267. doi: 10.3390/nu13093267. Nutrients. 2021. PMID: 34579143 Free PMC article.
Next generation sequence (NGS) analysis indicated a modulation of the expression levels of several cardiac hypertrophy-associated genes, including GPR22, Myh7, Nppa, P2RX4, and Npy by MFE. Subsequent RT-PCR indicated that MFE regulated the expression levels of genes respon …
Next generation sequence (NGS) analysis indicated a modulation of the expression levels of several cardiac hypertrophy-associated genes, inc …
Adenosine triphosphate as a stimulant for nociceptive and non-nociceptive muscle group IV receptors in the rat.
Reinöhl J, Hoheisel U, Unger T, Mense S. Reinöhl J, et al. Neurosci Lett. 2003 Feb 20;338(1):25-8. doi: 10.1016/s0304-3940(02)01360-5. Neurosci Lett. 2003. PMID: 12565132
Single fibre activity was recorded from group IV afferents innervating the rat gastrocnemius-soleus muscle. Using mechanical stimuli the fibres were classified as nociceptive or non-nociceptive ones. ...Results were: (1) ATP at a concentration that is present in muscle …
Single fibre activity was recorded from group IV afferents innervating the rat gastrocnemius-soleus muscle. Using mechanical stimuli …
Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats.
Stefanova NA, Maksimova KY, Rudnitskaya EA, Muraleva NA, Kolosova NG. Stefanova NA, et al. BMC Genomics. 2018 Feb 9;19(Suppl 3):75. doi: 10.1186/s12864-018-4480-9. BMC Genomics. 2018. PMID: 29504901 Free PMC article.
According to RNA-Seq data analysis, major alterations in cerebrovascular processes of OXYS rats were associated with blood vessel development, circulatory system processes, the VEGF signaling pathway, and vascular smooth muscle contraction. At preclinical and early stages …
According to RNA-Seq data analysis, major alterations in cerebrovascular processes of OXYS rats were associated with blood vessel developmen …
Lack of run-down of smooth muscle P2X receptor currents recorded with the amphotericin permeabilized patch technique, physiological and pharmacological characterization of the properties of mesenteric artery P2X receptor ion channels.
Lewis CJ, Evans RJ. Lewis CJ, et al. Br J Pharmacol. 2000 Dec;131(8):1659-66. doi: 10.1038/sj.bjp.0703744. Br J Pharmacol. 2000. PMID: 11139444 Free PMC article.
Immunoreactivity for P2X(1), P2X(4) and P2X(5) receptor subtypes was detected in the smooth muscle cell layer of second and third order rat mesenteric arteries immunoreactivity, for P2X(2), P2X(3), P2X(6) and P2X(7) receptors was below the level of detection in the smooth …
Immunoreactivity for P2X(1), P2X(4) and P2X(5) receptor subtypes was detected in the smooth muscle cell layer of second and third ord …
30 results